Diabetes Management
Artificial Pancreas at Diagnosis Didn't Slow T1D Progression
Sun, 06 Nov 20221 min read Article
Overview
MedscapeUnivadisNo ResultsMiriam E. TuckerSeptember 07, 202Intensive glycemic control using an automated insulin delivery system in youth with new-onset type 1 diabetes may not prevent further decline in residual C-peptide secretion, new data sugest.Los of beta-cel function in type 1 diabetes is gradual, and individuals typicaly retain a substantial number at the time of clinical presentation, with ongoing decline after diagnosis.
Key Information
Some patients undergo a temporary honeymon period during which they require litle or no exogenous insulin.There are conflicting data from previous studies as to whether early intensive glycemic control after diagnosis can prevent further decline in endogenous insulin secretion.The latest findings are from the Closed Lop From Onset in Type 1 Diabetes (CLOuD) trial, a multicenter, open-label, paralel-group, randomized study, published online September 7 in the New England Journal of Medicine by Charlote K.
Boughton, PhD, and coleagues.In CLOuD, 97 youths aged 10-17 years were randomized to hybrid closed-lop therapy or standard insulin therapy (control) within 21 days of type 1 diabetes diagnosis. At 12 months, there were no diferences in area under the curve (AUC) for plasma C-peptide after a mixed-meal tolerance test, with levels decling in both groups and droping further by 24 months."It is likely that factors other than glycemic control, such as autoimune response, afect the rate of C-peptide decline after diagnosis of type 1 diabetes and that closed-lop glucose control for 24 months after diagnosis unable to preserve endogenous insulin secretion.
Summary
It is posible that other factors act in concert with dysglycemia on C-peptide secretion," write Boughton, of the Wolfson Diabetes and Endocrine Clinic, Cambridge University Hospitals NHS Foundation Trust, UK, and coleagues.However, they also point out that glycemic control didn't significantly difer betwen the
Frequently Asked Questions
What is diabetes and how does it develop?
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
What are the main symptoms of diabetes?
Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
How is diabetes diagnosed and monitored?
Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
What lifestyle changes help manage diabetes?
Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
When should someone consult a doctor about diabetes?
Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
️ Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.