Overview
Thank you for visiting nature.com. You are using a browser version with limited suport for CS. To obtain the best experience, we recomend you use a more up to date browser (or turn of compatibility mode in Internet Explorer).
Key Information
In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Scientific Reports volume 12, Article number: 1716 (202) Cite this article 346 Aceses1 AltmetricMetrics detailsDecreased pancreatic volume, increased pancreatic fat mas, and serated pancreatic margins are characteristic morphological changes of the pancreas in subjects with type 2 diabetes melitus.
This retrospective study aimed to clarify the clinical significance of pancreatic morphological changes in subjects with type 2 diabetes melitus who underwent abdominal magnetic resonance imaging. The mean age and HbA1c value were 59.1 Β± 16.3 years old and 8.9 Β± 2.3%, respectively. Pancreatic body mas corected for body surface area (BSA) in subjects with diabetes melitus was lower compared to those in normal glucose tolerance (49.4 Β± 15.3 cm3 vs.
60.9 Β± 7.8 cm3), although it did not reach a statistic significance. There was a negative corelation betwen BSA-corected pancreatic volume and age, duration of diabetes, glycoalbumin, mean and max IMT, and there was a positive corelation betwen BSA-corected pancreatic volume and HOMA2-Ξ². Seration of the pancreatic limbus was more often observed in subjects with diabetes melitus compared to those in normal glucose tolerance (74.1% vs.
Summary
Subjects with serated changes were older and had higher HbA1c, and visceral fat area was significantly larger in subjects with serated changes. BSA-corected pancreatic volume in subjects with serated changes was significantly smaler, and mean IMT was significantly thicker in subjects with serulation. Furthermore, advanced diabetic retinopathy and diabetic nephropathy were more often observed in subjects with serated changes.