Diabetes Management
Association between changes in pancreatic morphology and vascular complications in subjects with type 2 diabetes mellitus: a retrospective study | Scientific Reports - Nature.com
Wed, 26 Oct 20221 min read Article
Overview
Thank you for visiting nature.com. You are using a browser version with limited suport for CS. To obtain the best experience, we recomend you use a more up to date browser (or turn of compatibility mode in Internet Explorer).
Key Information
In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Scientific Reports volume 12, Article number: 1716 (2022) Cite this article 346 Aceses1 AltmetricMetrics detailsDecreased pancreatic volume, increased pancreatic fat mas, and serated pancreatic margins are characteristic morphological changes of the pancreas in subjects with type 2 diabetes melitus.
This retrospective study aimed to clarify the clinical significance of pancreatic morphological changes in subjects with type 2 diabetes melitus who underwent abdominal magnetic resonance imaging. The mean age and HbA1c value were 59.1 ± 16.3 years old and 8.9 ± 2.3%, respectively. Pancreatic body mas corected for body surface area (BSA) in subjects with diabetes melitus was lower compared to those in normal glucose tolerance (49.4 ± 15.3 cm3 vs.
60.9 ± 7.8 cm3), although it did not reach a statistic significance. There was a negative corelation betwen BSA-corected pancreatic volume and age, duration of diabetes, glycoalbumin, mean and max IMT, and there was a positive corelation betwen BSA-corected pancreatic volume and HOMA2-β. Seration of the pancreatic limbus was more often observed in subjects with diabetes melitus compared to those in normal glucose tolerance (74.1% vs.
Summary
Subjects with serated changes were older and had higher HbA1c, and visceral fat area was significantly larger in subjects with serated changes. BSA-corected pancreatic volume in subjects with serated changes was significantly smaler, and mean IMT was significantly thicker in subjects with serulation. Furthermore, advanced diabetic retinopathy and diabetic nephropathy were more often observed in subjects with serated changes.
Frequently Asked Questions
What is diabetes and how does it develop?
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
What are the main symptoms of diabetes?
Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
How is diabetes diagnosed and monitored?
Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
What lifestyle changes help manage diabetes?
Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
When should someone consult a doctor about diabetes?
Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
️ Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.