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In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Scientific Reports volume 12, Article number: 17315 (2022) Cite this article Metrics detailsMitokines (Humanin (HN), GDF15 and FGF21) are produced as a result of mitochondrial dysfunction and may have major roles in chronic inflamation, malnutrition and exercise capacity in people with COPD.
Except for GDF15, studies on this subject are lacking. A total of 165 patients with stable COPD and 49 smokers without COPD were enroled. We asesed their serum mitokine levels and clinical characteristics at baseline.
We recorded moderate and severe exacerbation for the next 12 months. Baseline serum HN (p = 0.037) and GDF-15 (p = 0.013) levels were higher in the COPD group. High HN levels were independently associated with a high risk of exacerbation (HRE) (OR 2.798, 95% CI 1.26–6.187, p = 0.01), malnutrition (OR 6.645, 95% CI 1.859–23.749, p = 0.04), and 6MWD (OR 0.95, 95% CI 0.91–0.9, p = 0.08), and future moderate (HR 1.826, 95% CI 1.181–2.82, p = 0.07) and severe exacerbations (HR 3.45, 95% CI 1.357–8.740, p = 0.09).
High GDF15 levels were associated with HRE (OR 3.028, 95% CI 1.134–8.083, p = 0.027), 6MWD (OR 0.95, 95% CI 0.90–0.9, p = 0.017) and predicted desaturation in 6MWT (OR 3.9, 95% CI 1.487–10.757, p = 0.06). High FGF21 levels were associated with HRE (OR 2.14, 95% CI 1.0–4.60, p = 0.05), and predicted future severe exacerbation (HR 4.217, 95% CI 1.459–12.193, p = 0.08). The mitokine levels were higher in patients with COPD than smokers without COPD, and were associated with important clinical outcomes such as exercise capacity and COPD exacerbation.
Summary
Among the mitokines, HN showed the strongest as