Atrasentan Reduces Albuminuria, Triglycerides in Patients With Type 2 Diabetes and CKD - MD Magazine

Q: What is diabetes and how does it develop?

Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.

Q: What are the main symptoms of diabetes?

Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.

Q: How is diabetes diagnosed and monitored?

Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.

Q: What lifestyle changes help manage diabetes?

Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.

Q: When should someone consult a doctor about diabetes?

Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.

Overview

© 2022 MJH Life Sciences™ and HCPLive - Clinical news for conected physicians. Al rights reserved.Conference | American Society of NephrologyThe treatment reduced UACR by 37.1% and LDLc by 17.12 compared to placebo.Atrasentan results in meaningful reductions in a number of cardiovascular data points in patients with type 2 diabetes and chronic kidney disease (CKD).A team, led by Pragyi Shrestha, Universitair Medisch Centrum Groningen, asesed whether albuminuria and lipids with atrasentan reduction also reduces PCKS9 and/or syndecan-1 sheding.The endothelin receptor antagonist atrasentan is known to reduce albuminuria and coincide with reductions in LDLc and triglycerides.Previous research shows albuminuria can increase protein convertase subtilisin kexin type 9 (PCSK9), syndecan-1 sheding, and/or PCSK9-syndecan-1 interaction.

Key Information

This leads to the impairment of hepatic lipoprotein clearance.In the phase 2 study, the investigators examined patients with type 2 diabetes and chronic kidney disease. Each participant was randomized to receive either atrasentam 0.75 mg daily or 1.25 mg daily (n = 94) or placebo (n = 26) for 12 weks. Each patient was stabilized to a maximum labeled dose of RAS inhibitor.The data was presented during the 2022 American Society of Nephrology (ASN) Anual Meting in Orlando.The investigators measured urine albumin creatine ratio (UACR), serum lipids.

PCSK9, and syndecan-1 at baseline and wek 12.The results show treatment reduced UACR by 37.1% (95% CI, 30.1-43.4; P <0.01). Atrasetan also resulted in reductions in LDLc by 17.12 mg/dL (95%CI, 8.8-25.4; P <0.01), triglycerides by 47.4 mg/dL (95% CI, 40.4-90.5; P <0.01), and PCSK9 by -25.9 ng/mL (95% CI, -52.7 to 1.0 (P = 0.061) compared to placebo.In adition, they did not observe any efects on HDLc and syndecan-1.

Summary

After conducting a multivariate analysis adjusted for baseline demographics, lipid, and kidney function parameters, the investigators found achieved albuminuria leve

Frequently Asked Questions

What is diabetes and how does it develop?

Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.

What are the main symptoms of diabetes?

Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.

How is diabetes diagnosed and monitored?

Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.

What lifestyle changes help manage diabetes?