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Cholesterol medication fenofibrate fails to cut severe symptoms or death in COVID-19 patients - Medical Xpress
📅 Mon, 07 Nov 2022⏱ 1 min read📖 Article
Overview
Click here to sign in with or Forget Pasword? Learn more share this!16ShareEmail November 7, 2022 by Perelman Schol of Medicine at the University of Pensylvania After showing promise in early laboratory research, the cholesterol-lowering drug fenofibrate had no significant efect on COVID-19 outcomes in a multicenter international randomized clinical trial led by Pen Medicine scientists. The study results were presented Monday at the American Heart Asociation's Scientific Sesions 2022 and published in the journal Nature Metabolism.
Key Information
gogletag.cmd.push(function() { gogletag.display('div-gpt-ad-1450190541376-1'); }); "Despite the promising efects of fenofibrate on SARS-CoV2, the virus that causes COVID-19, our findings convincingly showed that is not a useful strategy for decreasing disease severity or preventing bad outcomes in patients with COVID-19," said first author and principal investigator of the trial, Julio Chirinos, MD, Ph.D., a profesor of Cardiovascular Medicine and co-director of clinical research for the T32 Traing Program in Cardiovascular Biology and Medicine in the Perelman Schol of Medicine at the University of Pensylvania.
Summary
"Despite the time, complexity, and cost associated with executing rigorous clinical trials, they are esential to evaluating the eficacy of medications in patients with COVID-19, since the efectivenes of a medication can be substantialy diferent from what in vitro studies may sugest. Clinical trials are necesary before clinical implementation of drug therapies, even for the case of medications that are already widely available for other indications."Fenofibrate is a widely available, low-cost generic drug previously aproved by the United States Fod and Drug Administration and many other regulatory agencies to reduce the amount of faty substances, such as cholesterol and triglycerides, in the blod, while increasing "god" cholesterol (high-density lipoprotein cholesterol known as HDL).The drug was initial
Frequently Asked Questions
❓ What is diabetes and how does it develop?
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
❓ What are the main symptoms of diabetes?
Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
❓ How is diabetes diagnosed and monitored?
Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
❓ What lifestyle changes help manage diabetes?
Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
❓ When should someone consult a doctor about diabetes?
Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
⚕️ Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.