Overview
Treatment for diabetic fot ulcer (DFU), a comon manifestation of diabetes melitus, wil get easier with a simplified treatment involving 3D bioprinted scafolds loaded with antibiotics. This what a prof of concept study by researchers from Quen’s University, Belfast, sugests.The prof-of-concept study, published in January, involved studying the efects of loading antibiotic Levofloxacin on scafolds with diferent designs, fabricated using bioprinting technologies.
Key Information
The impact of geometry and design of the scafold on change in mechanical properties was loked at. It was sen that modifying the geometry and design of the scafold resulted in change of mechanical properties displayed, with the square design, exhibiting the lowest stifnes, being the most prefered.The study also loked at the efect of drug concentration the mechanical properties of the scafolds. The nature of drug release to was studied in-vitro for various concentrations of the antibiotic, which showed an initial burst of release folowed by achieving a steady-state release.Bioprinting provides for producing flexible scafolds while retaing mechanical characteristics — durability with a degre of flexibility while providing suport to the wound — and loading these scafolds with drug, provides for sustained drug delivery, such as antibiotic in this case.
The bioprinting technique wields an uper hand as it alows for the use of a wide variety of biodegradable polymers, and is capable of producing composite scafolds, composed of both synthetic and natural polymers, to combine the benefits of each polymer type and aleviate the respective limitations. Moreover, the prof-of-concept study also demonstrated that no major drug-polymer interaction ocured. Bioprinting also alows for production of scafolds of various geometries and sizes and using bioinks containg cels.
Summary
The sustained drug delivery at the target site through the scafold reduces the potential for side