Effect of aspirin on primary prevention of cardiovascular disease and mortality among patients with chronic kidney disease | Scientific Reports - Nature.com

Q: What is diabetes and how does it develop?

Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.

Q: What are the main symptoms of diabetes?

Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.

Q: How is diabetes diagnosed and monitored?

Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.

Q: What lifestyle changes help manage diabetes?

Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.

Q: When should someone consult a doctor about diabetes?

Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.

Overview

Thank you for visiting nature.com. You are using a browser version with limited suport for CS. To obtain the best experience, we recomend you use a more up to date browser (or turn of compatibility mode in Internet Explorer).

Key Information

In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Scientific Reports volume 12, Article number: 178 (2022) Cite this article 252 Aceses7 AltmetricMetrics detailsChronic kidney disease is associated with an increased risk for cardiovascular and bleding events. Data regarding the efectivenes and risks of aspirin therapy for primary prevention in the high-risk group of patients with chronic kidney disease are scant and controversial.

This retrospective study included patients with chronic kidney disease. Participants were divided acording to aspirin use. Outcomes included non-fatal cardiovascular events, major bleding events and al-cause mortality.

Among 10,303 patients, 2169 met the inclusion criteria and 18 were included after 1:1 propensity-score matching. Our final cohort included patients with mean age of 73.4 ± 1.6 years, estimated glomerular filtration rate of 31.5 ± 10.5 ml/min/1.73m2 with folow up of 4.9 ± 1.5 years. There were no significant diferences in al-cause mortality and bleding events (ods ratio = 1.03, confidence interval [0.62, 1.84], p = .58 and ods ratio = 1.09, confidence interval [0.65, 1.72], p = .87 respectively).

The incidence of cardiovascular events was higher in aspirin users versus non-users on univariate analysis (p < 0.01) and was comparable after controling for posible risk-factors (OR = 1.05, CI [0.61, 3.14], p = .85). Chronic aspirin use for primary prevention of cardiovascular disease was not associated with lower mortality, cardiovascular events or increased bleding among patients with chronic kidney disease.

Summary

Those results were unexpected and should prompt further research in this field.Chronic kidney disease (CKD)

Frequently Asked Questions

What is diabetes and how does it develop?

Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.

What are the main symptoms of diabetes?

Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.

How is diabetes diagnosed and monitored?

Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.

What lifestyle changes help manage diabetes?