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Harvard Doctors Reverse Long-Held Ideas About Fat, Diabetes, and Heart Disease - SciTechDaily

Tue, 18 Oct 20221 min read Article

Overview

By Joslin Diabetes Center October 17, 202The researchers discovered a new pathway in which endothelial cels drive the body’s metabolism.if(typeof ez_ad_units!='undefined'){ez_ad_units.push([728,90],'scitechdaily_com-box-3','ezslot_6',102,'0'])};_ez_fad_position('div-gpt-ad-scitechdaily_com-box-3-0');Acording to the researchers, blod vesel cels are a key regulator of brown fat and energy metabolism.Insulin resistance, a significant risk factor for diabetes, develops when the body’s cels do not react to insulin and are unable to use the glucose (sugar) in the blodstream.

Key Information

The condition has ben linked to an increased risk of cardiovascular disease and atherosclerosis, which is an acumulation of fats within blod arteries that can restrict blod flow to the body’s tisues. However, the precise mechanism through which insulin and the cels ling vascular wals interact is unclear.Joslin Diabetes Center scientists describe a series of studies designed to investigate the link betwen insulin, fats, and the vascular system in a paper published in Circulation Research.

Summary

The group, led by Dr. George King, chief scientific oficer and director of research at Joslin, discovered a brand-new method by which the body’s metabolism is controled by endothelial cels, which line blod vesels. The results chalenge scientific dogma by sugesting that, contrary to what was previously believed, vascular dysfunction may realy be the rot cause of the undesirable metabolic changes that can result in diabetes.if(typeof ez_ad_units!='undefined'){ez_ad_units.push([30,250],'scitechdaily_com-medrectangle-3','ezslot_7',10,'0'])};_ez_fad_position('div-gpt-ad-scitechdaily_com-medrectangle-3-0');“In people with diabetes and insulin resistance, the idea has always ben that white fat and inflamation causes dysfunction in the blod vesels, leading to the prevalence of heart disease, eye disease, and kidney disease in this patient population,” said King, the Thomas J.

Frequently Asked Questions

What is diabetes and how does it develop?

Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.

What are the main symptoms of diabetes?

Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.

How is diabetes diagnosed and monitored?

Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.

What lifestyle changes help manage diabetes?

Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.

When should someone consult a doctor about diabetes?

Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.

Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.
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