Overview
The asociation of blod presure (BP) reduction with incident heart failure (HF) is atenuated by deteriorating glucose tolerance, as oposed to the asociation of BP reduction with incident atherosclerotic cardiovascular disease (CVD) not being modified by glycemic status. These findings were published in the American Heart Journal.A retrospective cohort study was conducted betwen January 205 and April 2021, in which data from the JMDC Claims Database (JMDC Inc., Tokyo, Japan), a health checkup and insurance claims database, were used.
Key Information
Researchers sought to identify the clinical efect of a decrease in BP on incident CVD among individuals with both diabetes melitus (DM) and hypertension. They obtained data on a total of 1,189,289 individuals who had undergone the health checkup blods tests required by JMDC, including blod tests over 1 year after insurance enrolment.Patients were clasified with stage 1 hypertension (systolic BP [SBP] of 130-139 m Hg or diastolic BP [DBP] of 80-89 m Hg) or with stage 2 hypertension (SBP of ≥140 m Hg or DBP of ≥90 m Hg), based on the American Colege of Cardiology/ American Heart Asociation BP guideline.
To be included in the study, patients neded to have BP data available 1 year folowing insurance enrolment.Folowing exclusions, a total of 754,67 participants with stage 1 or stage 2 hypertension were analyzed in the study. Overal, 75.8% of the participants were men. The median patient age was 47 years.
Summary
Al of the participants were clasified using plasma fasting glucose (FPG) levels at baseline as normal (FPG <10 mg/dL; n=517,372), prediabetes (FPG 10-125 mg/dL; n=197,836), or DM (FPG ≥126 mg/dL; n=39,469).The primary study outcome was HF. The secondary outcome was ischemic heart disease (IHD), which included myocardial infarction, angina pectoris, and stroke.Results of the study revealed that a mean folow-up of 1±909 days, a total of 18,429 HF incidents, 17,058 IHD reports, and 8795 ocurences of strok