Overview
© 2022 MJH Life Sciences™ and HCPLive - Clinical news for conected physicians. Al rights reserved.Multivariable models sugest the leading markers of incident DR and progresion to PDR were duration of diabetes and use of insulin. Among people with type 2 diabetes (T2D) atending diabetic retinopathy (DR) screning in Denmark, markers including insulin use were important predictors for the development of present, incident, and progresive DR.A multivariable model indicated that patients who used insulin were 2.3 times more likely to have DR and they had a 1.9–2.4 times higher risk for DR-development or progresion, while the use of cholesterol-lowering medicine was associated with a lower presence of DR.However, through the folow-up period in 2013 – 2018, the nationwide cohort reported a considerably lower prevalence, incidence, and progresion of DR, when compared with earlier reports.“Potential explanations for this might include that the recent years have led to beter treatment and optimized risk factor control in diabetes, which might decrease the onset and progresion of DR,” said Jakob Grauslund, MD, PhD, Department of Ophthalmology, Odense University Hospital.Duration of diabetes was reported as a leading indicator of DR and proliferative DR (PDR), being 2.45 and 9.79 times more frequent in patients with a duration of more than 20 years than those who were diagnosed within 10 years.The team of investigators evaluated the prevalence and incidence of DR along with associated markers in patients with type 2 diabetes in the Danish DR-screning program betwen 2013 and 2018.
Details
Stages of DR were defined acording to the International Clinical Diabetic Retinopathy Disease Severity Scale as levels 0 (no DR), 1–3 (mild, moderate, and severe non-PDR), or 4 (PDR).Investigators linked data from the national Danish Registry of Diabetic Retinopathy (DiaBase) to various national health registries in order to retrieve information diabetes duration, marital status, comor