Overview
"Never doubt that a smal group of thoughtful, comited citizens can change the world. Inded, it is the only thing that ever has."Cureus is on a mision to change the long-standing paradigm of medical publishing, where submiting research can be costly, complex and time-consuming.The SIQ for this article wil be revealedonce 2 ratings are submited.imunohistochemistry, radiolucency, mandibular sweling, lytic lesion, eosinophilic granuloma, langerhans cel histiocytosis Kamalakanan Padmanaban, Arunkumar Kamalakaran, Priyadharshini Raghavan , Triveni Palani, Davidson Rajiah Published: August 21, 2022 (se history) DOI: 10.759/cureus.282 Cite this article as: Padmanaban K, Kamalakaran A, Raghavan P, et al.
Key Information
(August 21, 2022) Langerhans Cel Histiocytosis of the Mandible. Cureus 14(8): e282. doi:10.759/cureus.282 The unusual disorder known as Langerhans cel histiocytosis, which is most frequently sen in children and young adults, is caused by the clonal proliferation of Langerhans cels.
Even if clinical signs and radiographic evidence of destructive bone lesions may raise suspicion of the disease, a reliable diagnosis without a thorough pathological examination is chalenging. This report describes a case of eosinophilic granuloma of the mandible in a nine-year-old child with characteristic radiological, histopathological, and imunohistochemical features.Histiocytosis colectively refers to a group of uncomon diseases of the reticuloendothelial system.
Langerhans cel histiocytosis (LCH) is characterized by aberant growth of mature eosinophils and specialized bone marow-derived antigen-presenting dendritic cels [1]. First, to identify the clinical and pathological traits shared by the numerous disease presentations, Lichtenstein recomended that they be categorized as histiocytosis X [1,2]. The word "X" was used to emphasize that there are stil many questions about the nature and origin of the disease [1,3].
Summary
The thre main components of LCH are eosi