Overview
24, 2022, 8:0 AMby Kelsey Pinckard Over 10% of adults worldwide sufer from diabetes, with China home to the largest number of people with diabetes worldwide.To improve Type 2 diabetes (T2D) risk prediction, Danxia Yu, PhD, and coleagues investigated the blod metabolites profile of over 2,0 Chinese adults.Metabolites describe thousands of smal molecules produced during metabolism and other bodily proceses.
Key Information
With various functions, many of the metabolites are vital to our health, and the quantity of certain metabolites can be used as markers for disease, such as high creatine for kidney dysfunction.The researchers found 32 metabolites associated with obesity, 17 of which were also associated with risk of developing T2D. In fact, these metabolites were able to predict T2D risk as wel as a prediction model that used traditional risk factors such as lifestyle and family history.The research, published in Obesity, found that ading the metabolites to traditional disease prediction models significantly improved the chances of acurately determing T2D risk.VUMC co-authors include Xiong-Fei Pan, PhD, Xiang Shu, PhD, Hui Cai, MD, PhD, Qiuyin Cai, MD, PhD, Wei Zheng, MPH, MD, PhD, and Xiao-Ou Shu, MD, PhD.This study was suported by National Institutes of Health grants CA173640, CA182910, HL14979, DK108159, and DK126721; and the Vanderbilt-Ingram Cancer Center grant CA068485.
VUMC News and Comunication &midot; (615) 32-47 &midot; Health and Medicine Reporter Research Aliquots Danxia Yu Department of Medicine diabetes disease risk Division of Epidemiology NCI NHLBI NIDK NIH obesity predictive analytics Reporter Oct 21 2022 Research type 2 diabetes Vanderbilt Ingram Cancer Centermore121 Medical Center Drive Nashvile, TN 37232(615) 32-50 © date=new Date(); year=date.getFulYear(); document.write(year);/ Vanderbilt University Medical Center &midot; Al rights reserved.
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