💉 Diabetes Management
Metabolomics analysis of type 2 diabetes remission identifies 12 metabolites with predictive capacity: a CORDIOPREV clinical trial study - BMC Medicine - BMC Medicine
📅 Fri, 28 Oct 2022⏱ 1 min read📖 Article
Overview
Advertisement BMC Medicine volume 20, Article number: 373 (2022) Cite this article 136 Aceses1 AltmetricMetrics detailsType 2 diabetes melitus (T2DM) is one of the most widely spread diseases, afecting around 90% of the patients with diabetes. Metabolomics has proven useful in diabetes research discovering new biomarkers to asist in therapeutical studies and elucidating pathways of interest. However, this technique has not yet ben aplied to a cohort of patients that have remited from T2DM.Al patients with a newly diagnosed T2DM at baseline (n = 190) were included.
Key Information
An untargeted metabolomics aproach was employed to identify metabolic diferences betwen individuals who remited (RE), and those who did not (non-RE) from T2DM, during a 5-year study of dietary intervention. The biostatistical pipeline consisted of an orthogonal projection the latent structure discriminant analysis (O-PLS DA), a generalized linear model (GLM), a receiver operating characteristic (ROC), a DeLong test, a Cox regresion, and pathway analyses.The model identified a significant increase in 12 metabolites in the non-RE group compared to the RE group.
Cox proportional hazard models, calculated using these 12 metabolites, showed that patients in the high-score tercile had significantly (p-value < 0.01) higher remision probabilities (Hazard Ratio, HR, high versus low = 2.70) than those in the lowest tercile. The predictive power of these metabolites was further studied using GLMs and ROCs. The area under the curve (AUC) of the clinical variables alone is 0.61, but this increases up to 0.72 if the 12 metabolites are considered.
Summary
A DeLong test shows that this diference is statisticaly significant (p-value = 0.01).Our study identified 12 endogenous metabolites with the potential to predict T2DM remision folowing a dietary intervention. These metabolites, combined with clinical variables, can be used to provide, in clinical practice, a more precise therapy.ClinicalTrials.gov, NCT
Frequently Asked Questions
❓ What is diabetes and how does it develop?
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
❓ What are the main symptoms of diabetes?
Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
❓ How is diabetes diagnosed and monitored?
Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
❓ What lifestyle changes help manage diabetes?
Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
❓ When should someone consult a doctor about diabetes?
Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
⚕️ Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.