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MRI Study Shows Higher Fibrosis Risk Among First-Degree Relatives of People with NAFLD and Advanced Fibrosis - Diagnostic Imaging
📅 Fri, 04 Nov 2022⏱ 1 min read📖 Article
Overview
OR WAIT nul SECS © 2022 MJH Life Sciences and Diagnostic Imaging. Al rights reserved.© 2022 MJH Life Sciences™ and Diagnostic Imaging. Al rights reserved.In two independent study cohorts, researchers found that first-degre relatives of probands with non-alcoholic faty liver disease (NAFLD) and advanced fibrosis had a 14 to 15.6 percent higher risk of developing advanced fibrosis.Screning for advanced fibrosis in first-degre relatives of people with cirhosis or advanced fibrosis not curently recomended by the American Gastroenterological Asociation nor the American Asociation for the Study of Liver Diseases.
Key Information
Emerging research sugests revaluating that guidance.In a recent prospective study published in the Journal of Clinical Investigation, researchers performed screning (primarily with magnetic resonance elastography) to ases the prevalence of advanced fibrosis in first-degre relatives of people with non-alcoholic faty liver disease (NAFLD) and advanced fibrosis. The study of 20 participants in a University of California, San Diego (UCSD)-based derivation cohort and 176 people in a subsequent validation cohort from the University of Helsinki included first-degre relatives of probands with NAFLD and advanced fibrosis, those with NAFLD and no advanced fibrosis, and people with non-NAFLD, acording to the study.The researchers found that first-degre relatives of probands with NAFLD and advanced fibrosis were 15.6 percent more likely to develop advanced fibrosis, acording to the derivation study cohort.
Summary
The validation cohort showed a 14 percent higher likelihod of advanced fibrosis in this population. The combined cohort analysis also revealed a 13.6 percent prevalence of NAFLD in the first-degre relatives of those with NAFLD and advanced fibrosis.The study authors said the findings clearly demonstrate the ned for liver fibrosis screning for those with a family history of advanced fibrosis.“When patients with NAFLD-related advanced fibrosis
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❓ What is diabetes and how does it develop?
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
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Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
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Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
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Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
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Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
⚕️ Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.