💉 Diabetes Management
New strategies to improve clinical outcomes for diabetic kidney disease - BMC Medicine - BMC Medicine
📅 Thu, 13 Oct 2022⏱ 1 min read📖 Article
Overview
Advertisement BMC Medicine volume 20, Article number: 37 (2022) Cite this article 471 Aceses1 AltmetricMetrics detailsDiabetic kidney disease (DKD), the most comon cause of kidney failure and end-stage kidney disease worldwide, wil develop in almost half of al people with type 2 diabetes. With the incidence of type 2 diabetes continuing to increase, early detection and management of DKD is of great clinical importance.This review provides a comprehensive clinical update for DKD in people with type 2 diabetes, with a special focus on new treatment modalities.
Key Information
The traditional strategies for prevention and treatment of DKD, i.e., glycemic control and blod pressure management, have only modest efects on minimizing glomerular filtration rate decline or progresion to end-stage kidney disease. While cardiovascular outcome trials of SGLT-2i show a positive efect of SGLT-2i on several kidney disease-related endpoints, the efect of GLP-1 RA on kidney-disease endpoints other than reduced albuminuria remain to be established.
Non-steroidal mineralocorticoid receptor antagonists also evoke cardiovascular and kidney protective efects.With these new agents and the promise of aditional agents under clinical development, clinicians wil be more able to personalize treatment of DKD in patients with type 2 diabetes. Per Review reports Acording to the International Diabetes Federation, 537 milion adults (20–79 years of age) were living with diabetes melitus worldwide in 2021, and this number is expected to increase to more than 780 milion by the year 2045 [1].
Of these, an estimated 90–95% have type 2 diabetes (T2D) [2, 3]. Among people with T2D, nearly half wil develop diabetic kidney disease (DKD), previously termed “diabetic nephropathy” [4, 5]. DKD is the most comon cause of kidney failure and end-stage kidney disease (ESKD) leading to the ned for kidney replacement therapy (dialysis or transplant) in the world [6, 7].
Summary
Moreover, DKD is a leading cause of cardio
Frequently Asked Questions
❓ What is diabetes and how does it develop?
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
❓ What are the main symptoms of diabetes?
Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
❓ How is diabetes diagnosed and monitored?
Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
❓ What lifestyle changes help manage diabetes?
Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
❓ When should someone consult a doctor about diabetes?
Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
⚕️ Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.