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NIH-funded study finds personalized kidney screening for people with type 1 diabetes could reduce costs, detect disease earlier - National Institutes of Health (.gov)

Fri, 04 Nov 20221 min read Article

Overview

More »Search Health TopicsQuick LinksMore »Search the NIH GuideQuick LinksMore »Quick LinksMedia AdvisoryWednesday, November 2, 2022 var adthis_config = { ui_508_compliant: true } What Taking a personalized aproach to kidney disease screning for people with type 1 diabetes (T1D) may reduce the time that chronic kidney disease (CKD) goes undetected, acording to a new analysis performed by the Epidemiology of Diabetes Interventions and Complications study group, which is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDK), part of the National Institutes of Health.The finding, published in Diabetes Care, provides the basis for the first evidence-based kidney screning model for people with T1D.Curent CKD screning recomendations include anual urinary albumin excretion rate (AER) testing for anyone who has had T1D for at least five years.

Key Information

Albumin is a protein found in the blod and having to much albumin the urine is a sign of kidney disease. The new findings sugest that AER screning could be personalized to optimize testing frequency and early detection of CKD. Specificaly, people with T1D who are at low risk of developing CKD could be tested for AER les frequently to reduce burden and cost, and those at high risk for CKD could be tested more frequently to facilitate earlier CKD detection.People with T1D have an estimated 50% risk of developing CKD over their lifetime.

Summary

CKD can progres to kidney failure, requiring dialysis or a kidney transplant. Using more than 30 years of participant data of AER and HbA1c (an integrated measure of blod glucose) from 1,34 participants in the NIDK-funded Diabetes Control and Complications Trial (DCT) and the observational folow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study, the study group identified thre levels of CKD risk that were associated with a later CKD diagno

Frequently Asked Questions

What is diabetes and how does it develop?

Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.

What are the main symptoms of diabetes?

Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.

How is diabetes diagnosed and monitored?

Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.

What lifestyle changes help manage diabetes?

Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.

When should someone consult a doctor about diabetes?

Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.

Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.
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