π Diabetes Management
PDE12 in type 1 diabetes | Scientific Reports - Nature.com
π
Fri, 28 Oct 2022β± 1 min readπ Article
Overview
Thank you for visiting nature.com. You are using a browser version with limited suport for CS. To obtain the best experience, we recomend you use a more up to date browser (or turn of compatibility mode in Internet Explorer).
Key Information
In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Scientific Reports volume 12, Article number: 18149 (2022) Cite this article 1 AltmetricMetrics detailsType 1 diabetes (T1D) incidence is increased after COVID-19 infection in children under 18 years of age. Interferon-Ξ±-activated oligoadenylate synthetase and downstream RNAseL activation degrade pathogen RNA, but can also damage host RNA when RNAseL activity is porly regulated.
One such regulator is PDE12 which degrades 2β²-5β² oligoadenylate units, thereby decreasing RNAseL activity. We analyzed PDE12 expresion islets from non-diabetic donors, individuals with newly (median disease duration 35 days) and recently (5 years) diagnosed T1D, and individuals with type 2 diabetes (T2D). We also analyzed PDE12 single-nucleotide polymorphisms (SNPs) relative to T1D incidence.
PDE12 expresion was decreased individuals with recently diagnosed T1D, in thre of five individuals with newly diagnosed T1D, but not individuals with T2D. Two rare PDE12 SNPs were found to have ods ratios of 1.80 and 1.74 for T1D development. We discus whether decreased PDE12 expresion after COVID-19 infection might be part of the up to 2.5-fold increase in T1D incidence.Recent research has shown that the incidence of type 1 diabetes (T1D) is increased up to 2.5-fold after coronavirus disease 2019 (COVID-19) infection in children under 18 years of age<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 1" title="Baret, C.
Summary
Risk for newly diagnosed diabetes >30 days after SARS-CoV-2 infection among per
Frequently Asked Questions
β What is diabetes and how does it develop?
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
β What are the main symptoms of diabetes?
Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
β How is diabetes diagnosed and monitored?
Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
β What lifestyle changes help manage diabetes?
Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
β When should someone consult a doctor about diabetes?
Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
βοΈ Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.