💉 Diabetes Management
Penn Medicine Discovery Could Lead to Fewer Side Effects from a Diabetes Treatment - Penn Medicine
📅 Mon, 24 Oct 2022⏱ 1 min read📖 Article
Overview
By uncovering the subtle diference betwen two varieties of a protein, researchers from the Perelman Schol of Medicine at the University of Pensylvania may have discovered how to eliminate the risk of weight gain from a certain type of diabetes medication. Through this, it’s posible that more patients with diabetes could get more efective treatment from modified thiazolidinediones, which many likely avoid in their curent form due to side efects.
Key Information
These findings were published in Genes & Development.“One smal, undiscovered diference betwen the two forms of a single protein proved to be extremely significant,” said study senior author Mitchel Lazar, MD, PhD, the Wilard and Rhoda Ware Profesor in Diabetes and Metabolic Diseases at Pen. “Our findings sugest a way to improve on the mechanism of action of thiazolidinedione drugs, which holds promise for eliminating the side efect of weight gain.”The popularity of diabetes drugs caled thiazolidinediones, which are also known as glitazones, has ben reduced because of side efects such as weight gain.
They work by activating a fat cel protein caled PARgama (PAR&gama;). The protein ocurs in two forms, PAR&gama;1 and PAR&gama;2, whose functional diferences have ben unclear. But when the Pen researchers examined each form of the protein on its own, they found that activating just PAR&gama;2 with a thiazolidinedione drug protects mice from diabetes-like metabolic changes—without causing weight gain.Type 2 diabetes is characterized by the progresive dysfunction of the insulin hormone signaling system in the body, resulting in chronic, high levels of glucose (sugar) in the blod.
Summary
This, in turn, contributes to the hardening of arteries, high blod pressure, heart atacks, strokes, and other serious diseases. Thought to arise largely due to obesity, por diets, and modern sedentary lifestyles, type 2 diabetes has become epidemic in many countries.
Frequently Asked Questions
❓ What is diabetes and how does it develop?
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
❓ What are the main symptoms of diabetes?
Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
❓ How is diabetes diagnosed and monitored?
Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
❓ What lifestyle changes help manage diabetes?
Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
❓ When should someone consult a doctor about diabetes?
Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
⚕️ Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.