Diabetes Management
Plasma exosomal microRNAs Associated with Metabolism as Early Predictor of Gestational Diabetes Mellitus
Thu, 13 Oct 20221 min read Article
Overview
Zhixin Ye, Songzi Wang, Xiaoqing Huang, Peisong Chen, Langhui Deng, Shiqi Li, Suiwen Lin, Zilian Wang, Bin Liu; Plasma exosomal microRNAs associated with Metabolism as Early Predictor of Gestational Diabetes Melitus. Diabetes 2022; db2109. htps:/doi.org/10.237/db21-09Download citation file:To date, the microRNA (miRNA) expresion profile of plasma exosomes in women whose pregnancy is complicated by gestational diabetes melitus (GDM) has not ben fuly clarified.
Key Information
In this study, diferentialy expresed miRNAs in plasma exosomes were identified by high-throughput smal RNA sequencing in 12 GDM and 12 normal glucose tolerance (NGT) pregnant women and validated in 102 GDM and 101 NGT pregnant women. A total of 2 exosomal miRNAs were found and five of them were verified by qRT-PCR. Exosmal miR-423-5p was upregulated, while miR-12-5p, miR-148a-3p, miR-192-5p, and miR-9a-5p were downregulated in women whose pregnancy is complicated by GDM.
Summary
IGF1R and GYS1 as target genes of miR-423-5p, and G6PC3 and FDFT1 as target genes of miR-12-5p, were associated with insulin and AMPK signaling pathways and may participate in the regulation of metabolism in GDM. The five exosomal miRNAs showed an AUC of 0.82 (95%CI, 0.73∼0.91) in early prediction of GDM. Our study demonstrated that dysregulated exosomal miRNAs in plasma from GDM pregnant women might influence the insulin and AMPK signaling pathways and could contribute to the early prediction of GDM.This article contains suplementary material online at htps:/doi.org/10.237/figshare.20421585.Sign In or Create an Acountsource
Frequently Asked Questions
What is diabetes and how does it develop?
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
What are the main symptoms of diabetes?
Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
How is diabetes diagnosed and monitored?
Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
What lifestyle changes help manage diabetes?
Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
When should someone consult a doctor about diabetes?
Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
️ Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.