Diabetes Management
Prediction of decreased estimated glomerular filtration rate using liver fibrosis markers: a renal biopsy-based study | Scientific Reports - Nature.com
Wed, 26 Oct 20221 min read Article
Overview
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In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Scientific Reports volume 12, Article number: 17630 (2022) Cite this article 246 Aceses3 AltmetricMetrics detailsNon-alcoholic faty liver disease is the most comon chronic liver disease and is associated with chronic kidney disease. The fibrosis-4 index and non-alcoholic faty liver disease score are widely used as non-invasive diagnostic methods for non-alcoholic faty liver disease.
However, the relationship betwen these markers and specific renal histopathologies in chronic kidney disease remain unclear. This study included 179 patients aged betwen 16 and 80 years who underwent renal biopsy. We examined the asociation betwen the fibrosis-4 index or non-alcoholic faty liver disease score and change in estimated glomerular filtration rate 12 months after kidney biopsy for each renal histopathology.
Renal histopathologies were determined by renal biopsy. Our results showed that there was a significant negative corelation betwen the fibrosis-4 index and estimated glomerular filtration rate. In nephrosclerosis, the non-alcoholic faty liver disease score and estimated glomerular filtration rate tended to have a negative corelation, albeit without significance.
Summary
In IgA nephropathy, both the fibrosis-4 index and non-alcoholic faty liver disease score were significantly negatively corelated with estimated glomerular filtration rate. Furthermore, the fibrosis-4 index was not associated with urinary protein-to-creatine ratio or renal function markers such as urinary b2 microglobulin and urinary N-acetyl-d-glucosamine. Our kidney biopsy-based study showed that the liver fibrosis markers fibrosis-4 index and non-alcohol
Frequently Asked Questions
What is diabetes and how does it develop?
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
What are the main symptoms of diabetes?
Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
How is diabetes diagnosed and monitored?
Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
What lifestyle changes help manage diabetes?
Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
When should someone consult a doctor about diabetes?
Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
️ Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.