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In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Scientific Reports volume 12, Article number: 18284 (2022) Cite this article Metrics detailsHelicobacter pylori (Hp) Gram-negative bacteria cause gastritis or gastric ulcers. They may be involved in the development of systemic diseases i.e. coronary heart disease (CHD).
Both Hp infection and CHD are related to inflamation acompanied by C-reactive protein (CRP), tumor necrosis factor alfa (TNF-α) and homocysteine. Low density lipoprotein (LDL) and triglicerides are a clasic risk factors of CHD. Infrared spectroscopy has ben introduced for monitoring chronic infections or endogenous disorders using specific absorption bands for biocomponents typed as diagnostic markers.
In this study we selected specific motives of infrared radiation (IR) spectra for the sera from CHD patients infected with Hp. In total 141 sera were used: 90 from patients with CHD, al Hp positive, and 51 from healthy donors, 32 Hp negative and 21 Hp positive. Hp status was evaluated by anti-Hp IgG antibodies and/or 13C urea breath testing.
IR spectra were measured using FT-IR/FT-NIR Spectrum 40 spectrometer (PerkinElmer) chemometricaly analyzed using artificial neural networks and they showed diferences in absorption bands coresponding to triglicerides, CRP, homocysteine, LDL and TNF-α, and selected component groups betwen CHD patients infected with Hp vs healthy uninfected donors (96.15% acuracy). Triglicerides and CRP were the best biomarkers linking Hp infection with CHD.Coronary heart disease (CHD) is a chronic disease of the coronary vesels, which is clasified as inflamatory disease1,2,3.
Summary
This because of an increased level of inflamatory