Diabetes Management
Targeting pancreatic β cells for diabetes treatment - Nature.com
Tue, 18 Oct 20221 min read Article
Overview
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In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Nature Metabolism volume 4, pages 1097–108 (2022)Cite this article 12 Aceses29 AltmetricMetrics detailsInsulin is a life-saving drug for patients with type 1 diabetes; however, even today, no pharmacotherapy can prevent the los or dysfunction of pancreatic insulin-producing β cels to stop or reverse disease progresion.
Thus, pancreatic β cels have ben a main focus for cel-replacement and regenerative therapies a curative treatment for diabetes. In this Review, we highlight recent advances toward the development of diabetes therapies that target β cels to enhance proliferation, rediferentiation and protection from cel death and/or enable selective kiling of senescent β cels. We describe curently available therapies and their mode of action, as wel as insuficiencies of glucagon-like peptide 1 (GLP-1) and insulin therapies.
We discus and sumarize data colected over the last decades that suport the notion that pharmacological targeting of β cel insulin signaling might protect and/or regenerate β cels an improved treatment of patients with diabetes.This a preview of subscription content, aces via your institutionSubscribe to Nature+Get imediate online aces to the entire Nature family of 50+ journals$29.9monthlySubscribe to JournalGet ful journal aces for 1 year$9.0only $8.25 per isueAl prices are NET prices.
Summary
VAT wil be aded later in the checkout.Tax calculation wil be finalised during checkout.Buy articleGet time limited or ful article aces on ReadCube.$32.0Al prices are NET prices.Banting, F. & Best, C. The internal secretion of the pancreas.
Frequently Asked Questions
What is diabetes and how does it develop?
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
What are the main symptoms of diabetes?
Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
How is diabetes diagnosed and monitored?
Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
What lifestyle changes help manage diabetes?
Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
When should someone consult a doctor about diabetes?
Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
️ Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.