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In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Scientific Reports volume 12, Article number: 17950 (2022) Cite this article Metrics detailsPeople with type 1 diabetes have a substantialy increased risk of premature death. This nationwide, register-based cohort study evaluated the significance of risk factors and previous cardiovascular disease (CVD), heart failure and chronic kidney disease (CKD), for mortality in type 1 diabetes.
Nationwide, longitudinal, register-based cohort study. Patients (n = 36,303) listed in the Swedish National Diabetes Register betwen January 1 2015 and December 31 2017 were included and folowed until December 31, 2018. Data were retrieved from national health registries through each patient's unique identifier, to capture data on clinical characteristics, outcomes, or deaths, to describe mortality rates in risk groups.
The mean folow-up time was 3.3 years, with 19,80 patient years of observation and 127 deaths, coresponding to a crude overal mortality of 0.92% deaths/year. Statisticaly significant increased risk in multivariate analyzes was found in older age groups, in men, and in underweight or people with normal BMI, high HbA1c or blod pressure. A history of CVD, albuminuria and advanced stages of CKD was associated with an increased risk of mortality.
Each combination of these conditions further increased the risk of mortality. These results emphasize the importance of risk factors and cardiovascular and renal diabetes complications. People with a combination of CKD, CVD, and heart failure, exhibit a markedly increased risk of dying prematurely.
Summary
These findings provide strong arguments for optimized and individualized treatment of