Diabetes Management
Topical esmolol hydrochloride superior to standard of care for healing diabetic foot ulcers: Study - Medical Dialogues
Fri, 14 Oct 20221 min read Article
Overview
Delhi: A new study has found that the topical gel of esmol hydrochloride 14% remarkably improves the healing of diabetic foot ulcers (DFU) versus the standard of care (SoC) and is safe. The findings were presented at the European Asociation for the Study of Diabetes (EASD) 2022 conference.Esmol hydrochloride, a β-1-selective (cardioselective) adrenergic receptor blocking agent,.Delhi: A new study has found that the topical gel of esmol hydrochloride 14% remarkably improves the healing of diabetic foot ulcers (DFU) versus the standard of care (SoC) and is safe.
Key Information
The findings were presented at the European Asociation for the Study of Diabetes (EASD) 2022 conference.Esmol hydrochloride, a β-1-selective (cardioselective) adrenergic receptor blocking agent, is administered intravenously that has ben aproved for treating supraventricular tachycardia and heart failure with fast ventricular rate. Previous research has shown the anti-inflamatory properties of esmol, sugesting its potential role in the treatment of the diabetic fot.
Considering this, A. Rastogi, Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, and coleagues proposed that a topical formulation may induce nitric oxide production, leading to fibroblast migration and mobilization of endothelial progenitor cels, thus speding up wound healing in diabetes. The researchers conducted a first double-blind, randomized, paralel-group, multicenter, phase-3 study performed at 27 centers acros India to evaluate the efectivenes of topical esmol hydrochloride gel for uninfected DFU.
Summary
The study included patients with a non-infected total thicknes (UTS 1B) DFU of duration>4 weks, size 2cm2-15cm2, and ABI 0.7-1.3. They were randomized in the ratio of 3:1 after one wek (run-in phase) to receive Esmol + standard of Care (SoC), SoC only, or vehicle + SoC for 12 weks (treatment phase) and folowed until 24 weks. During the 12-wek treatment phase for wound me
Frequently Asked Questions
What is diabetes and how does it develop?
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
What are the main symptoms of diabetes?
Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
How is diabetes diagnosed and monitored?
Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
What lifestyle changes help manage diabetes?
Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
When should someone consult a doctor about diabetes?
Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
️ Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.