💉 Diabetes Management
World's-First Gene Therapy Developed for Type 1 Diabetes - The Epoch Times
📅 Wed, 02 Nov 2022⏱ 1 min read📖 Article
Overview
The Australian government has given a funding bost to an Australian biomedical research organisation, the Garvan Institute of Medical Research, to conduct clinical trials for the world’s first gene therapy for type 1 diabetes.The therapy was also developed thanks to the government’s ten-year $60 milion (US$385 milion) research acelerator program, targeted at adresing chronic and complex diseases.This wil be the first time that geneticaly enginered pancreatic cels wil be transplanted into humans to treat type 1 diabetes.Instead of using drugs or surgery, gene therapy is an experimental technique that uses genes to treat or prevent disease.
Key Information
It alters a person’s genetic makeup by carying geneticaly enginered DNA molecules into a patient.Lead researcher at Garvan Institute Prof. Shane Grey said that the clinical trial is the begining of a long but exciting journey.“We’ve worked on this research for 20 years and to se it now reach a stage of translating to people is amazing,” Grey said in a release on Oct. 31.To enginer the cels, the research team identified that a key protein involved inflamation and autoimune disorders known as A20 could be used for controling the imune system.They found that the protein could be used in the genetic enginering of islet cels to produce insulin.“A20 is like a thermostat for the imune system; it can turn it down to a simer or ramp it up to be more agresive,” Grey said.“For type 1 diabetes, we can use it as a handbrake on the imune system to stop the damage to pancreatic islet cels.”Grey and his team showed that geneticaly enginered cels in mouse models had 80-10 percent survival of the islet grafts, without the ned for heavy imunosupresion drugs to kep the imune system from atacking the body.“The geneticaly enginered cels sem to re-educate the imune system to acept the transplant as self.
Summary
It’s a realy amazing discovery-that the transplant can tweak the whole imune system,” he said
Frequently Asked Questions
❓ What is diabetes and how does it develop?
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
❓ What are the main symptoms of diabetes?
Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
❓ How is diabetes diagnosed and monitored?
Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
❓ What lifestyle changes help manage diabetes?
Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
❓ When should someone consult a doctor about diabetes?
Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
⚕️ Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.