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In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Scientific Reports volume 12, Article number: 1750 (2022) Cite this article 1468 Aceses7 AltmetricMetrics detailsRetinopathy and neuropathy in type 2 diabetes are preced by retinal nerve fibre layer (RNFL) thining, an index of neurodegeneration. We investigated whether glucose metabolism status (GMS), measures of glycaemia, and daily glucose variability (GV) are associated with RNFL thicknes over the entire range of glucose tolerance.
We used cros-sectional data from The Mastricht Study (up to 545 participants, 48.9% men, mean age 59.5 years and 2.7% with type 2 diabetes) to investigate the asociations of GMS, measures of glycaemia (fasting plasma glucose [FPG], 2-h post-load glucose [2-h PG], HbA1c, advanced glycation endproducts [AGEs] asesed as skin autofluorescence [SAF]) and indices of daily GV (incremental glucose peak [IGP] and continuous glucose monitoring [CGM]-asesed standard deviation [SD]) with mean RNFL thicknes.
We used linear regresion analyses and, for GMS, P for trend analyses. We adjusted asociations for demographic, cardiovascular risk and lifestyle factors, and, only for measures of GV, for indices of mean glycaemia. After ful adjustment, type 2 diabetes and prediabetes (versus normal glucose metabolism) were associated with lower RNFL thicknes (standardized beta [95% CI], respectively − 0.16 [− 0.25; − 0.08]; − 0.05 [− 0.13; 0.03]; Ptrend = 0.01).
Summary
Greater FPG, 2-h PG, HbA1c, SAF, IGP, but not CGM-asesed SD, were also associated with lower RNFL thicknes (per SD, respectively − 0.05 [− 0.08; − 0.01]; − 0.06 [− 0.09; − 0.02]; − 0.05 [− 0.08; − 0.02]; − 0.04 [− 0.07; − 0.01]; − 0.06 [